This is the recording and slides of the session presented live at the 2023 AcCELLerate Forum: Creating a Sustainable Ecosystem of Cell and Gene Therapy. The event aired live on Monday, October 2, 2023. 

Topics include:

• Engineered Cell Therapies: Where Were We? Where Are We? Where Are We Going? 
• Approval Strategies for New Therapies
• Regulatory Process for Approval in the CD 19 Space and Beyond

Session Chairs:

• Marcelo Pasquini, MD, MS; CIBMTR and MCW
• Peter Marks, MD, PhD; FDA

Speakers: 

• Bruce Levine, PhD; University of Pennsylvania
• David Chang, MD, PhD; Allogene
• Nicole Verdun, MD; FDA

This is the recording and slides of the session presented live at the 2023 AcCELLerate Forum: Creating a Sustainable Ecosystem of Cell and Gene Therapy. The event aired live on Monday, October 2, 2023. 

Topics include:

• Updates on the ASTCT’s 80/20 Subcommittee Initiatives: A World without REMS?
• FDA Resources for Innovative Cell and Gene Therapies
• Challenges in Mass Manufacturing of CAR-T Engines: Viral Vectors
• Access and Disparities in the Quest for Cell Therapies: Current Challenges and Potential Solutions

Session Chairs:

• Armin Ghobadi, MD; Washington University School of Medicine
• Rayne Rouce, MD; Baylor College of Medicine/Texas Children's Hospital 

Speakers: 

• Sarah Nikiforow, MD, PhD; Dana-Farber Cancer Institute 
• Rob Sokolic, MD; FDA
• Adrian Gee, PhD; Center for Cell & Gene Therapy, Baylor College of Medicine Houston
• Rayne Rouce, MD; Baylor College of Medicine/Texas Children's Hospital 

This is the recording and slides of the session presented live at the 2023 AcCELLerate Forum: Creating a Sustainable Ecosystem of Cell and Gene Therapy. The event aired live on Tuesday, October 3, 2023.

Topics include:

• Prevention and Management of Refractory CRS
• Emergent Neurotoxicities
• Immune Effector Cell-associated HLH-like Syndrome
• Immune Effector Cell Associated Hematotoxicity(ICAHT): European Guidelines

Session Chairs:

• Nirali Shah, MD, MHSc; National Cancer Institute 
• Kevin McNerney, MD, MSc; Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine

Speakers: 

• Michael Jain, MD, PhD; Moffitt Cancer Center
• Bianca Santomasso, MD, PhD; Memorial Sloan Kettering Cancer Center
• Kevin McNerney, MD, MSc; Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine
• Marion Subklewe, MD; University Hospital Munich 

This is the recording and slides of the session presented live at the 2023 AcCELLerate Forum: Creating a Sustainable Ecosystem of Cell and Gene Therapy. The event aired live on Tuesday, October 3, 2023.

Topics include:

• Allogeneic vs Autologous Therapies and How they Compete
• Alternative Targets: Beyond B-Cell Malignancies
• Allogeneic NK Cell Platform for Cancer Immunotherapy

Session Chair:

• Matthew Frigault, MD; MGH

Speakers: 

• Jay Spiegel, MD; University of Miami, Sylvester Comprehensive Cancer Center
• Rayne Rouce, MD; Baylor College of Medicine/Texas Children's Hospital 
• Veronika Bachanova, MD, PhD; University of Minnesota

Panelist:

• Elizabeth Shpall, MD; MD Anderson Cancer Center

This is the recording and slides of the session presented live at the 2023 AcCELLerate Forum: Creating a Sustainable Ecosystem of Cell and Gene Therapy. The event aired live on Monday, October 2, 2023.

Topics include:

• Building a Cellular Therapy Program: Inpatient & Outpatient
• Building your Program to be Able to Adapt to Solid Tumors
• Is there an Optimal Cell Therapy Service Structure?

Session Chair:

• Sairah Ahmed, MD; MD Anderson Cancer Center

Speakers: 

• Krish Patel, MD; Swedish Cancer Institute 
• Samer Srour, MB ChB, MS; MD Anderson Cancer Center
• Gunjan Shah, MD, MS; Memorial Sloan Kettering Cancer Center

This is the recording and slides of the session presented live at the 2023 AcCELLerate Forum: Creating a Sustainable Ecosystem of Cell and Gene Therapy. The event aired live on Monday, October 2, 2023.

Topics include:

• Biological Drivers of CAR T Cell Failure
• Patient-Specific Factors Impacting CAR T Cell Efficacy

Session Chair:

• Shannon Maude, MD, PhD; Children's Hospital of Pennsylvania/Perelman School of Medicine at the University of Pennsylvania

Speakers: 

• Nathan Singh, MD; Washington University School of Medicine
• Regina Myers, MD; Children's Hospital of Pennsylvania/Perelman School of Medicine at the University of Pennsylvania

This is the recording and slides of the session presented live at the 2023 AcCELLerate Forum: Creating a Sustainable Ecosystem of Cell and Gene Therapy. The event aired live on Monday, October 2, 2023.

Topics include:

• Bispecifics vs CARs
• Sequencing Bispecific Antibody Therapies and CAR-T cells in Multiple Myeloma
• Future Directions for Solid Tumors

Session Chair:

• Neha Korde, MD; Memorial Sloan Kettering Cancer Center

Speakers: 

• Syed Abbas Ali, MD; John Hopkins University 
• Neha Korde, MD; Memorial Sloan Kettering Cancer Center
• Roisin O’Cearbhaill, MD; Memorial Sloan Kettering Cancer Center

This is the recording and slides of the session presented live at the 2023 AcCELLerate Forum: Creating a Sustainable Ecosystem of Cell and Gene Therapy. The event aired live on Monday, October 2, 2023.

Topics include:

• Equity of Access to HCT/ Cell Therapy
• Need to Reduce Business Operations Complexity in Advancing Patients Through Cellular Therapy Treatment
• Developing Tools to Widen Patient Access to Complex Therapies

Session Chair:

• Amy Emmert, MScPH, Dana-Farber Cancer Institute

Speakers: 

• Nandita Khera, MD, MPH; Mayo Clinic AZ 
• Amy Emmert, MScPH, Dana-Farber Cancer Institute
• Robert Richards, MS, MBA; Penn Medicine

This is the recording and slides of the session presented live at the 2023 AcCELLerate Forum: Creating a Sustainable Ecosystem of Cell and Gene Therapy. The event aired live on Monday, October 2, 2023.

Topics include:

• Pearls of Cellular Therapy Manufacturing Logistics
• Clinical Use of Mesenchymal Stem Cells (MSCs) and MSC-Exosomes: Immune Suppression, Regenerative Medicine, and Gene Delivery
• Virus-Specific T Cells

Session Chair:

• Elizabeth Shpall, MD; MD Anderson Cancer Center

Speakers: 

• Ray Hornung, MBA, MBCI, CEM, CBCP; NMDP
• Elizabeth Shpall, MD; MD Anderson Cancer Center
• Adrian Gee, PhD; Center for Cell & Gene Therapy, Baylor College of Medicine Houston

This is the recording and slides of the session presented live at the 2023 AcCELLerate Forum: Creating a Sustainable Ecosystem of Cell and Gene Therapy. The event aired live on Monday, October 2, 2023.

Topics include:

• CAR-T Barriers to Care
• Point of Care Manufacture of CAR T cells
• Point of Care Manufacturing: Enabling affordable and accessible advanced medicines

Session Chair:

• Boro Dropulić, PhD, MBA; Caring Cross

Speakers: 

• Armin Ghobadi, MD; Washington University School of Medicine
• Marcos de Lima, MD; The Ohio State University Comprehensive Cancer Center
• Boro Dropulić, PhD, MBA; Caring Cross