ASTCT Pharmacy SIG Journal Club - March 2025

The ASTCT Pharmacy SIG March 2025 Journal Club will air on Wednesday, March 26 at 2 pm CT/3 pm ET. This webinar will consist of two, 30-minute journal club presentations, which include 20 minutes for the presentation and 10 minutes for discussion and a Q&A session. In this Journal Club session, Drs. Ortiz and Tran will present two articles related to: (a) Vedolizumab for the prevention of intestinal acute GVHD after allo-HSCT and (b) safety and efficacy of obecabtagene autoleucel in adults with B-Cell acute lymphoblastic leukemia.

Presenters & Articles:

Kristina Ortiz, PharmD

PGY-2 Pharmacy Resident

UCHealth – University of Colorado Hospital

Article: Vedolizumab for the prevention of intestinal acute GVHD after allogeneic hematopoietic stem cell transplantation: a randomized phase 3 trial

Hanh Tran, PharmD

PGY-2 Pharmacy Resident

Wellstar MCG Health

Article: Obecabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia

Session Learning Objectives:

Upon completion of the activity, participants should be able to:

• Review current graft-versus-host disease (GVHD) prophylaxis regimens for matched unrelated donor (MUD) hematopoietic stem cell transplantation (HSCT)
• Analyze the safety and efficacy of vedolizumab combined with calcineurin inhibitors with methotrexate or mycophenolate mofetil for acute intestinal GVHD prophylaxis
• Discuss the role of vedolizumab as GVHD prophylaxis for matched unrelated HSCT
• Describe the epidemiology, pathophysiology, and treatment of B-cell acute lymphoblastic leukemia
• Discuss the differences between CAR-T therapies in the management of B-cell acute lymphoblastic leukemia
• Evaluate the role of obecabtagene autoleucel in adults with relapsed, refractory B-cell acute lymphoblastic leukemia

ACCREDITED PROVIDER

This activity is jointly provided by The France Foundation and American Society for Transplantation and Cellular Therapy (ASTCT).

In support of improving patient care, this activity has been planned and implemented by The France Foundation and American Society for Transplantation and Cellular Therapy (ASTCT). The France Foundation is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

CREDIT DESIGNATION

Pharmacists

This knowledge-based activity qualifies for 1.0 contact hours (0.10 CEUs) of continuing pharmacy education credit. Please submit all evaluations and credit requests no later than 30 days after you complete this activity to ensure your credit fulfillment, as CE credit cannot be awarded past 60 days from the activity date. Your CE credits will be electronically submitted to the NABP upon successful completion of the activity. Pharmacists with questions can contact NABP customer service (custserv@nabp.net).

All other healthcare professionals completing this course will be issued a statement of participation.

The full CE information for this session will be available soon.