ASTCT Pharmacy SIG Journal Club - November 2025

The ASTCT Pharmacy SIG November 2025 Journal Club aired on Wednesday, November 19 at 2 p.m. CT/3 p.m. ET. The webinar consisted of two, 30-minute journal club presentations, which included 20 minutes for the presentation and 10 minutes for discussion and a Q & A session. In the November Journal Club session, Drs. Donovan and Santos presented two articles related to:

• PTCy-based GVHD Prophylaxis after mismatched unrelated donor peripheral blood stem cell transplant
• CAR-T Therapy for Richter Transformation

Presenters & Articles:

Daniel Donovan, PharmD

PGY-2 Pharmacy Resident

MD Anderson Cancer Center

Article: Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis After Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

Cheyenne Santos, PharmD

PGY-2 Pharmacy Resident

Oregon Health & Sciences University

Article: Chimeric Antigen Receptor T-Cell Therapy for Richter Transformation: A CIBMTR Analysis

Session Learning Objectives:

Upon completion of the activity, participants should be able to:

• Review current evidence and clinical practices for graft-versus-host disease (GVHD) prophylaxis following hematopoietic stem cell transplantation (HSCT)
• Evaluate the utility and clinical significance of PTCy-based prophylaxis in mismatched unrelated donor (MMUD) transplantation among various conditioning regimens
• Review current treatment recommendations for relapsed refractory Richer transformation
• Evaluate the safety and efficacy of anti-CD19 CAR-T therapy for patients with relapsed refractory Richter transformation 
• Summarize the role of anti-CD19 CAR-T therapy for patients with relapsed refractory Richter transformation

ACCREDITED PROVIDER

This activity is jointly provided by The France Foundation and American Society for Transplantation and Cellular Therapy (ASTCT).

In support of improving patient care, this activity has been planned and implemented by The France Foundation and American Society for Transplantation and Cellular Therapy (ASTCT). The France Foundation is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

CREDIT DESIGNATION

Pharmacists

This knowledge-based activity qualifies for 1.0 contact hour (0.10 CEU) of continuing pharmacy education credit. Please submit all evaluations and credit requests no later than 30 days after you complete this activity to ensure your credit fulfillment, as CE credit cannot be awarded past 60 days from the activity date. Your CE credits will be electronically submitted to the NABP upon successful completion of the activity. Pharmacists with questions can contact NABP customer service (custserv@nabp.net).

All other healthcare professionals completing this course will be issued a statement of participation.

The full accreditation information for this session can be found here.