ASTCT Pharmacy SIG Journal Club - September 2024

The ASTCT Pharmacy SIG September 2024 Journal Club will air on Wednesday, September 11, 2024 at 2 pm CDT/3 pm EDT. This webinar consists of two, 30-minute journal club presentations, which include 20 minutes for the presentation and 10 minutes for discussion and a Q&A session. In the September Journal Club session, Drs. Sawiris and Held will present on two articles related to: (a) Exagamglogene Autotemcel for severe sickle cell disease and (b) Safety and efficacy of eltrombopag for platelet engraftment after haploidentical bone marrow transplant. This session is intended for pharmacists and other members of the health care team who are involved in managing patients undergoing hematopoietic stem cell transplant or cell and gene therapy.

Presenters & Articles

Monica Sawiris, PharmD

PGY-2 Pharmacy Resident

Atrium Health Wake Forest Baptist

Article: Exagamglogene Autotemcel for Severe Sickle Cell Disease

Hailey Held, PharmD

PGY-2 Pharmacy Resident

UW Health - Carbone Cancer Center

Article: Eltrombopag improves platelet engraftment after haploidentical bone marrow transplantation: Results of a Phase II study

Session Learning Objectives:

Upon completion of the activity, participants should be able to:

• Explain the pathophysiology of sickle cell disease and limitations of existing treatments
• Define the mechanism of action of Exagamglogene autotemcel (exa-cel)
• Discuss safety and efficacy of Exagamglogene autotemcel (exa-cel) use in sickle cell disease
• Explore benefits and challenges associated with Exagamglogene autotemcel (exa-cel) use in sickle cell disease
• Describe the typical timeline for platelet engraftment after a haploidentical bone marrow transplant, risks associated with delayed engraftment, and supportive care options
• Review safety and efficacy of eltrombopag for platelet engraftment after a haploidentical bone marrow transplant
• Summarize the potential benefit and risk to patient if using eltrombopag to enhance platelet engraftment

ACCREDITED PROVIDER

This activity is jointly provided by The France Foundation and American Society for Transplantation and Cellular Therapy (ASTCT).

In support of improving patient care, this activity has been planned and implemented by The France Foundation and American Society for Transplantation and Cellular Therapy (ASTCT). The France Foundation is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

CREDIT DESIGNATION

Pharmacists

This knowledge-based activity, UAN JA0007204-9999-24-088-L01-P, qualifies for 1.0 contact hours (0.10 CEUs) of continuing pharmacy education credit. Please submit all evaluations and credit requests no later than 30 days after you complete this activity to ensure your credit fulfillment, as CE credit cannot be awarded past 60 days from the activity date. Your CE credits will be electronically submitted to the NABP upon successful completion of the activity. Pharmacists with questions can contact NABP customer service (custserv@nabp.net).

All other healthcare professionals completing this course will be issued a statement of participation.

The full CE information for this session can be found here.