The Learning Center

Diagnosing and Assessing Chronic Graft-versus-Host Disease

In this 20 minute module, Dr. Kirsten Williams from Children’s Healthcare of Atlanta reviews the most recent NIH consensus statements on diagnosis, staging, and response scoring of chronic graft-versus-host disease after hematopoietic stem cell transplant.  The current focus in this area is early detection. This is a first in a series of three modules addressing unmet needs in chronic graft versus host disease.

Activity Title: Diagnosing and Assessing Chronic Graft-versus-Host Disease

Topic: cGVHD

Accreditation Type: AMA PRA Category 1 Credit(s)™ 

Release Date: 12/2021

Expiration Date: 12/2022

Estimated Time to Complete Activity: 20 mins

Upon completion of the activity, participants should be able to:
• Discuss recent and ongoing updates to guidelines and consensus statements for cGvHD

Steven Pavletic, MD, MS
Head, Graft-Versus-Host Disease and Late Effects Section
Center for Cancer Research
National Institute of Health
Bethesda, MD

Kirk Schultz, MD
Investigator, Michael Cuccione Childhood Cancer Research Program
Director, Michael Cuccione Childhood Cancer Research Program
British Columbia Children’s Hospital
Professor, Division of Hematology and Oncology and Department of Pediatrics
University of British Columbia
Vancouver, BC

Kirsten Williams, MD
Pediatric Hematologist/Oncologist, Aflac Cancer & Blood Disorders Center
Children’s Healthcare of Atlanta
Associate Professor of Pediatrics
Emory University School of Medicine
Atlanta, GA

Olaf Penack, MD
Department of Hematology, Oncology and Tumor Immunology
Charité-Universitätsmedizin Berlin
Berlin, Germany 

Technical Requirements:
1. There are no fees for participating in and receiving credit for this activity 
2. Review the activity objectives and CME/CE information
3. Complete the CME/CE activity 
4. Complete the online posttest. A score of at least 75% is required to successfully complete this activity. The participant may take the test until successfully passed.
5. Complete the CME/CE evaluation/attestation form. This form provides each participant with the opportunity to comment on how participating in the activity will affect their professional practice; the quality of the instructional process; the perception of enhanced professional effectiveness; the perception of commercial bias; and his/her views on future educational needs.
6. Credit documentation/reporting:
• If you are requesting AMA PRA Category 1 Credits™ or a certificate of participation—your CME/CE certificate will be available for download

This activity is provided by The France Foundation and produced in collaboration with the American Society for Transplantation and Cellular Therapy (ASTCT).

This activity is intended for oncologists, hematologists, physician assistants, nurse practitioners, pharmacists, and other health care professionals involved in treating and managing patients with cGVHD.

A significant number of patients—some 30% to 70%—will develop cGvHD after allo-HSCT. It typically manifests during the first year after transplantation, but it can occur several years later. cGvHD is also the leading cause of non-relapse mortality in allo-HSCT patients. The earliest possible diagnosis is critical, as once patients meet diagnostic criteria for GvHD, they may have already developed significant morbidity and possibly even irreversible organ damage. Guidelines and consensus statements from the National Institutes of Health (National Cancer Institute; NIH/NCI), the European Society for Blood and Marrow Transplantation (ESBMT), and the National Comprehensive Cancer Network (NCCN) exist to help diagnose, stage, and manage cGvHD. Unfortunately, uptake and use of guidelines have been inconsistent and variable.

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of The France Foundation and American Society for Transplantation and Cellular Therapy. The France Foundation is accredited by the ACCME to provide continuing medical education for physicians.

The France Foundation designates this enduring activity for a maximum of 0.25 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

In accordance with the ACCME Standards for Commercial Support, The France Foundation (TFF) and American Society for Transplantation and Cellular Therapy (ASTCT) require that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial interest. TFF and ASTCT resolve all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all their educational programs. Furthermore, TFF and ASTCT seek to verify that all scientific research referred to, reported, or used in a CME/CE activity conforms to the generally accepted standards of experimental design, data collection, and analysis. TFF and ASTCT are committed to providing learners with high-quality CME/CE activities that promote improvements in health care and not those of a commercial interest.

Activity Staff Disclosures 
The planners, reviewers, editors, staff, CME committee, or other members at The France Foundation who control content have no relevant financial relationships to disclose.

The planners, reviewers, staff, or other members at American Society for Transplantation and Cellular Therapy who control content have no relevant financial relationships to disclose.

Faculty Disclosures - Content Creators 
The faculty listed below report that they have no relevant financial relationships to disclose:
• Kirsten Williams, MD
• Kirk Schultz, MD

The following faculty report that they have relevant financial relationships to disclose: 
• Olaf Penack, MD, has done non-CE consulting for Jazz, Gilead, MSD, Omeros, Priothera, Shionogi, and SOBI. He has served on the speaker’s bureau for Astellas, Gilead, Jazz, MSD, Neovii Biotech, Novartis, Pfizer, and Therakos. He has also done contract research for Gilead, Incyte, Jazz, Neovii Biotech, and Takeda.
• Steven Pavletic, MD, MS has done contract research for Kadmon, Eli Lilly, and Pharmacyclins.

TFF and ASTCT require CME faculty (speakers) to disclose when products or procedures being discussed are off label, unlabeled, experimental and/or investigational, and any limitations on the information that is presented, such as data that are preliminary, or that represent ongoing research, interim analyses, and/or unsupported opinion. Faculty in this activity may discuss information about pharmaceutical agents that is outside of US Food and Drug Administration approved labeling. This information is intended solely for continuing medical education and is not intended to promote off-label use of these medications. TFF and ASTCT do not recommend the use of any agent outside of the labeled indications. If you have questions, contact the Medical Affairs Department of the manufacturer for the most recent prescribing information. 

This activity is supported by an educational grant from Incyte.

The France Foundation and American Society for Transplantation and Cellular Therapy present this information for educational purposes only. The content is provided solely by faculty who have been selected because of recognized expertise in their field. Participants have the professional responsibility to ensure that products are prescribed and used appropriately on the basis of their own clinical judgment and accepted standards of care. The France Foundation, American Society for Transplantation and Cellular Therapy, and the commercial supporter(s) assume no liability for the information herein.

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If you have questions about this CME activity, please contact The France Foundation at 860-434-1650 or


Module - Diagnosing and Assessing Chronic GVHD
Begin self-paced component package.
Begin self-paced component package.