The June 2023 Pharmacy SIG Journal Club will air on Wednesday, June 7 from 2-3 PM CDT. In the June Journal Club session, Drs. Chen and Scott will present on two articles related to use of (a) defibrotide for prophylaxis of sinusoidal obstruction syndrome and (b) allogeneic transplant in newly diagnosed patients with AML following venetoclax/azacytidine or intensive induction. This session is intended for pharmacists and other members of the health care team who are involved in managing patients undergoing allogeneic stem cell transplant. 

Presenters & Articles

Teaghan Chen, PharmD

PGY-2 Pharmacy Resident

Children’s Hospital Colorado

Defibrotide plus best standard of care compared with best standard of care alone for the prevention of sinusoidal obstruction syndrome (harmony): a randomised, multicentre, phase 3 trial

Campbell Scott, PharmD

PGY-2 Pharmacy Resident

University of Georgia

Outcomes Are Similar After Allogeneic Hematopoietic Stem Cell Transplant for Newly Diagnosed Acute Myeloid Leukemia Patients who Received Venetoclax + Azacitidine Versus Intensive Chemotherapy

Session Learning Objectives:

Upon completion of the activity, participants should be able to:

1. Describe current standards of care in the prevention of sinusoidal obstruction syndrome
2. Evaluate the safety and efficacy of defibrotide use for the prevention of sinusoidal obstruction syndrome
3. Compare sinusoidal obstruction syndrome outcomes in patients that received defibrotide plus standard of care standard versus care alone
4. Summarize the role of venetoclax plus azacitidine in the treatment of patients with newly diagnosed acute myeloid leukemia
5. Compare post-allogeneic hematopoietic stem cell transplant outcomes between patients who received initial induction with venetoclax plus azacitidine or an intensive chemotherapy regimen

ACCREDITED PROVIDER

This activity is jointly provided by The France Foundation and American Society for Transplantation and Cellular Therapy (ASTCT).

In support of improving patient care, this activity has been planned and implemented by The France Foundation and American Society for Transplantation and Cellular Therapy (ASTCT). The France Foundation is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

CREDIT DESIGNATION

Pharmacists

This knowledge-based activity qualifies for 1.0 contact hours (0.10 CEUs) of continuing pharmacy education credit. Please submit all evaluations and credit requests no later than 30 days after you complete this activity to ensure your credit fulfillment, as CE credit cannot be awarded past 60 days from the activity date. Your CE credits will be electronically submitted to the NABP upon successful completion of the activity. Pharmacists with questions can contact NABP customer service (custserv@nabp.net).

All other healthcare professionals completing this course will be issued a statement of participation.

The full CE information for this session, including presenter disclosures and accreditation information, will be available soon.

Join ASTCT Director of Government Relations, Alycia Maloney, JD, and the reimbursement and policy advisors to ASTCT from Nimitt Consulting, for the FY 2024 IPPS Proposed Rule webinar on May 17 at 12 p.m. CDT.

Maloney and Nimitt will cover:

• Important IPPS Updates
  • Proposed consolidation of CC/MCC MS-DRGs and its impact on IPPS
  • Proposed changes to the New Technology Add-On Payment (NTAP) process
• CAR-T Therapy Updates:
  • Proposed payment policy for MS-DRG 018 for CAR-T therapy and changes to CMS’ special rate-setting methodology for MS-DRG 018, and update on the fixed-loss outlier threshold
  • Proposed expiration of NTAP for three CAR-T therapy products
• Stem Cell Transplant Updates:
  • Overall payment update and relative weight increases
  • CMS’ proposal for handling the weights of MS-DRGs 016 and 017
  • ICD-10-PCS procedure code mappings to the transplant MS-DRGs
  • Additional key updates to be aware of

There will be a Q&A section at the end of the webinar, so be sure to register and submit any questions in advance that you would like answered during the webinar to info@astct.org. If you are unable to join, the recording will be made available.

Please consider sharing this webinar with your network of doctors, administrators, providers, or any other colleagues that may be interested.

ASTCT April Journal Club Session

This journal club aired live on April 19, 2023, as a part of the expanded ASTCT Journal Club, and in partnership with the ASTCT Infectious Disease Special Interest Group. This webinar consisted of two, 30-minute journal club presentations, which included 20 min for presentation and 10 min for discussion/Q and A.

Presenters & Articles:

Dr. Rich Kodama, Memorial Sloan Kettering Cancer Center

Mentor: Dr. Aliyah Baluch, Moffitt Cancer Center

Maribavir for Refractory Cytomegalovirus Infections With or Without Resistance Post-Transplant: Results From a Phase 3 Randomized Clinical Trial

Dr. Jessica Little, Harvard University

Mentor: Dr. Ella Ariza, MD Anderson Cancer Center

Cytomegalovirus (CMV) Cell-Mediated Immunity and CMV Infection After Allogeneic Hematopoietic Cell Transplantation: The REACT Study

Join our expert panelists in this roundtable webinar to discuss unmet needs in graft-versus-host disease (GVHD). In this webinar, our moderator Dr. Noa Holtzman (National Cancer Institute of NIH) leads a discussion with expert panelists Dr. Betty Hamilton (Cleveland Clinic) and Dr. Shernan Holtan (University of Minnesota) about the recent advancements and anticipated future developments in GVHD. Topics discussed include: an overview of the current state of GVHD, advancements in GVHD prevention and treatment, how to better care for GVHD patients, and future changes in the field. This webinar is supported by the GVHD Alliance in honor of the first ever GVHD Day on Friday, February 17, at the 2023 Tandem Meetings of ASTCT & CIBMTR. The GVHD Alliance and GVHD Day are supported by Sanofi.

ASTCT January Journal Club Session

This journal club aired live on January 18, 2023, as a part of the expanded ASTCT Journal Club. This webinar consisted of two, 30-minute journal club presentations, which included 20 min for presentation and 10 min for discussion/Q and A.

Presenters & Articles

Dr. Ahsan Kamal, University of Arizona

Posttransplant cyclophosphamide for prevention of graft-versus-host disease: results of the prospective randomized HOVON-96 trial

Dr. Ronald Funk, Emory University

Targeting cancer-associated fibroblasts in the bone marrow prevents resistance to CART-cell therapy in multiple myeloma

This is the recording and slides of the session presented live at the 2022 AcCELLerate Forum: Creating a Sustainable Ecosystem of Cell and Gene Therapy. The event aired live on Friday, November 18, 2022. 

Topics include:

• CAR T vs ASCT in NHL
• Treatment Sequencing, including 2^nd CAR (myeloma)
• New Technologies
• Off the Shelf CAR
• Building Trial Efficiencies, Optimal Trial Design, Building Efficiencies

Session Chairs:

• Miguel-Angel Perales (Memorial Sloan Kettering Cancer Center)
• Catherine Bollard (Children’s National Hospital)

Speakers: 

• Miguel-Angel Perales (Memorial Sloan Kettering Cancer Center)
• Damian Green (Fred Hutch)
• Aude Chapuis (Fred Hutch)
• Carlos Ramos (Baylor)
• JoyceLynn Palmer (City of Hope) 

Panelists:

• Nina Shah (AstraZeneca)
  

This is the recording and slides of the session presented live at the 2022 AcCELLerate Forum: Creating a Sustainable Ecosystem of Cell and Gene Therapy. The event aired live on Friday, November 18, 2022. 

Topics include:

• IFNy pathway and CAR T-cell toxicities
• IL-1 targeting with CRS and ICANS
• HLH-like toxicities and CAR T-cells
• CNS-tumor targeting of CAR T-cells
• ASH CAR T Toxicity Project Update 

Session Chairs:

• Nirali Shah (NCI)
• Amy Moskop (MCW -CIBMTR) 

Speakers: 

• Marcela Maus (MGH)
• Jae Park (MSKCC)
• Nirali Shah (NCI)
• Robbie Majzner (Stanford)
• Fabiana Perna (Indiana University) 

Panelists:

• Noelle Frey (University of Pennsylvania) 

This is the recording and slides of the session presented live at the 2022 AcCELLerate Forum: Creating a Sustainable Ecosystem of Cell and Gene Therapy. The event aired live on Thursday, November 17, 2022. 

Topics include:

• Background and Update on 80/20
• FDA Programs: The Purpose and Current Processes for REMS, EAPs, BLA 
• EAPs in CART Therapy: Site Challenges and Opportunities for Improvement 
• REMS &Education in CART Therapy: Site Challenges and Opportunities for Improvement 
• BLA and Audits: Site Challenges and Opportunities for Improvement 

Session Chairs:

• Noelle Frey (University of Pennsylvania)
• Partow Kebriaei (MD Anderson Cancer Center) 

Speakers: 

• Fred Locke (Moffitt Cancer Center)
• Peter Marks (FDA)
• Matthew Frigault (MGH)
• Sarah Nikiforow (Dana Farber Cancer Institute)
• Rebecca Gardner (Seattle Children’s Hospital) 

Panelists:

• Robb Richards (University of Pennsylvania)
• Madan Jagasia (Iovance)

This is the recording and slides of the session presented live at the 2022 AcCELLerate Forum: Creating a Sustainable Ecosystem of Cell and Gene Therapy. The event aired live on Thursday, November 17, 2022. 

Topics include:

• Center Specific Outcomes from a Payers Perspective 
• Center Specific Outcomes from a Center Perspective 
• Center Specific Outcomes from a Data Collection/Analysis Perspective
• Race & Ethnic Disparities in Access and Outcomes: An Update on ASTCT/NMDP Access Initiative 

Session Chairs:

• Jeff Auletta (NMDP)
• Anthony Bonagura (Optum) 

Speakers: 

• Jeff Auletta (NMDP)
• Anthony Bonagura (Optum) 
• Navneet Majhail (Sarah Cannon)
• Patty Steinert (CIBMTR)

Panelists:

• Marcelo Pasquini (CIBMTR)
• Stephanie Farnia (Nimmit Consulting)

These are the recordings and slides of the four sessions from the live virtual event the 2022 AcCELLerate Forum: Creating a Sustainable Ecosystem of Cell and Gene Therapy, hosted by ASTCT™, the CIBMTR® and the National Marrow Donor Program®(NMDP)/Be The Match®. This live event took place on November 17 and 18, 2022. This two-day, virtual workshop offered providers, payers, government agencies, and industry involved in the field of cell and gene therapy increased educational and advocacy opportunities. This new workshop featured educational sessions bridging the gap among stakeholders, and identify ongoing needs and opportunities in the field for advocacy, measurement of value and impact, and sustainability.

Purchase this package to get access to all four sessions at a discounted rate! Individuals who registered to attend this event live are eligible to receive access to these recordings free of charge. Please email info@astct.org to receive your discount.